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Pre-Crystallization Test Kits - Creative Biostructure is specialized in providing cost-effective contract services to both academia and biotech/pharmaceutical industries in the field of structural biology and membrane protein technologies. We have developed all-in-one, gene-to-structure pipelines for the structure determination of macromolecules of your interest. With a team of experienced professionals, Creative Biostructure is able to solve the structure of many challenging proteins including GPCRs, ion channels, transporters, enzymes and viral targets. We also provide a comprehensive list of products and other related services to facilitate your research in structural biology.
Protein Crystallization Tool - Creative Biostructure is specialized in providing cost-effective contract services to both academia and biotech/pharmaceutical industries in the field of structural biology and membrane protein technologies. We have developed all-in-one, gene-to-structure pipelines for the structure determination of macromolecules of your interest. With a team of experienced professionals, Creative Biostructure is able to solve the structure of many challenging proteins including GPCRs, ion channels, transporters, enzymes and viral targets. We also provide a comprehensive list of products and other related services to facilitate your research in structural biology.
COVID-19 crystal structure determination - A new highly pathogenic coronavirus (SARS-CoV-2, provisionally named 2019-nCoV) has swept the world since December 2019. The key to responding to this outbreak is to understand the pathogenic mechanism of the virus. Our understanding of the viral infection process at the molecular and atomic levels depends on the ability to map the structural details of individual biological macromolecules and their interactions with each other and with small molecules. The determination of the three-dimensional (3D) structures of proteins is essential for understanding these interactions and their structure-function relationships, which is beneficial for scientists to develop more effective preventive or therapeutic drugs more quickly. With advanced facilities and years of experience in crystallization and structure determination, Creative Biostructure provides flexible X-ray crystallography services covering all technical stages from gene synthesis to structural analysis to support coronavirus-related research.
SARS-CoV-2 multi-wavelength anomalous dispersion - The quality of X-ray diffraction data of the protein crystal can determine the success rate of the subsequent steps of structure determination and the reliability of the reconstructed three-dimensional (3D) structural model. After successfully obtaining high-quality crystals for X-ray diffraction, Creative Biostructure supports the collection of X-ray diffraction data to facilitate protein structural analysis and drug candidate screening involved in the research of coronavirus infection.
zebrafish drug screening - Zebrafish (Danio rerio) possesses the physiology complexity of mammalian animals and is one of the most common vertebrate model organisms. Creative Biostructure establishes the MagHelix™ Zebrafish Screening Platform for medical research. Zebrafish is an excellent choice to model various diseases and screen novel drugs for medical and therapeutic research. Zebrafish larvae have been used increasingly within the last decade to assess the effects of chemical compounds.
fragment based drug discovery - Creative Biostructure has established a MagHelix™ FBDD Platform for early drug discovery, which covers advanced biophysical detection instruments, such as the X-ray single crystal diffractometer, high-performance nuclear magnetic resonance (NMR) instrument, and surface plasmon resonance (SPR) instrument. With the FBDD platform, we can provide customized drug discovery solutions for a wide variety of disease areas and therapeutic targets, including complex targets involving protein-protein interactions (PPI).
Confocal laser scanning microscopy - Creative Biostructure provides microscopy imaging services with a range of cutting-edge instruments, mainly including scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM). Our advanced EM platform and high experimental skills enable structural analysis and chemical mapping that allow our customers the in-depth observation of their samples with unmatched accuracy and speed. To investigate materials, parts, and devices, including defects, deformations, multilayer film stacks, particles, researchers and professionals choose Creative Biostructure.
Environmental Toxicants Analysis - At the iEM Platform, Creative Biostructure uses advanced microscopy technologies that can help analyze multiple pollutants and evaluate toxicity such as cytotoxicity and genotoxicity of contaminants, contributing to a better understanding of contamination issues in the environment.