In the field of cancer research, understanding the tumor microenvironment (TME) and its molecular mechanisms is essential for developing effective therapeutic strategies. Alfa Cytology offers exceptional molecular biology services for TME research.

Molecular Mechanisms in TME Targeting specific molecules or pathways in the TME shows promise for developing novel therapeutic strategies against tumor growth, metastasis, and treatment resistance. Tumor cells evade immune surveillance within the TME by upregulating immune checkpoint molecules like PD-L1 and inducing chronic inflammation through NF-κB signaling and cytokines such as TNF-α and IL-6. They secrete immunosuppressive factors like TGF-β and IL-10 to suppress immune responses and promote immune escape. Tumors promote angiogenesis through HIF-1α and VEGF, leading to impaired drug delivery and immune cell infiltration. Molecular biology services offer valuable insights into gene expression patterns, protein profiles, genetic alterations, epigenetic modifications, and functional properties of key molecules within the TME. By employing techniques such as next-generation sequencing (NGS), single-cell sequencing, quantitative polymerase chain reaction (qPCR), and DNA methylation profiling, researchers can uncover key molecular mechanisms driving TME dysregulation. Learn more：tme molecular biology services